Published Work

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2025

Y. Shamay, “Mastering the complexities of cancer nanomedicine with text mining, AI and automation,” J. Controlled Release, vol. 379, pp. 906–919, Mar. 2025, doi: 10.1016/j.jconrel.2025.01.057. Link

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2024

M. Avrashami, D. Niezni, D. Meron Azagury, H. Sason, and Y. Shamay, “Green/red fluorescent protein disrupting drugs for real‐time permeability tracking in three‐dimensional tumor spheroids,” Bioeng. Transl. Med., p. e10731, Dec. 2024, doi: 10.1002/btm2.10731. Link

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Tiwari, A., Haj, N., Elgrably, B., Berihu, M., Laskov, V., Barash, S., Zigron, S., Sason, H., Shamay, Y., Karni-Ashkenazi, S., Holdengreber, M., Saar, G., & Vandoorne, K. (2024). Cross-modal imaging reveals nanoparticle uptake dynamics in hematopoietic bone marrow during inflammation. ACS Nano, 18(9), 7098–7113. https://doi.org/10.1021/acsnano.3c11201 Link

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Taub-Tabib, H., Shamay, Y., Shlain, M., Pinhasov, M., Polak, M., Tiktinsky, A., Rahamimov, S., Bareket, D., Eyal, B., Kassis, M., Goldberg, Y., Kaminski Rosenberg, T., Vulfsons, S., & Ben Sasson, M. (2024). Identifying symptom etiologies using syntactic patterns and large language models. Scientific Reports, 14(1), 16190. https://doi.org/10.1038/s41598-024-65645-6. Link

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2023

Opatovski, N., Nehme, E., Zoref, N., Barzilai, I., Orange Kedem, R., Ferdman, B., Keselman, P., Alalouf, O., & Shechtman, Y. (2024). Depth-enhanced high-throughput microscopy by compact PSF engineering. Nature Communications, 15, 4861. https://doi.org/10.1038/s41467-024-48502-y. Link

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Tylawsky, D. E., Kiguchi, H., Vaynshteyn, J., Gerwin, J., Shah, J., Islam, T., Boyer, J. A., Boué, D. R., Snuderl, M., Greenblatt, M. B., Shamay, Y., Raju, G. P., & Heller, D. A. (2023). P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis. Nature Materials, 22(3), 391–399. https://doi.org/10.1038/s41563-023-01481-9. Link

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D. Niezni, H. Taub-Tabib, Y. Harris, H. Sason, Y. Amrusi, D. Meron-Azagury, M. Avrashami, S. Launer-Wachs, J. Borchardt, M. Kusold, A. Tiktinsky, T. Hope, Y. Goldberg, and Y. Shamay, “Extending the boundaries of cancer therapeutic complexity with literature text mining,” Artificial Intelligence in Medicine, vol. 145, p. 102681, 2023, doi: 10.1016/j.artmed.2023.102681. Link

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D. M. Azagury, B. F. Gluck, Y. Harris, Y. Avrutin, D. Niezni, H. Sason, and Y. Shamay, “Prediction of cancer nanomedicines self-assembled from meta-synergistic drug pairs,” Journal of Controlled Release, vol. 360, pp. 418–432, Aug. 2023, doi: 10.1016/j.jconrel.2023.06.040. Link

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Cohen, M., Shamay, Y., Czamanski-Cohen, J., Shulman, K., Rosenberg, S. K., Abu-Amna, M., Turgeman, I., Livshits, L. M., Birenboim, R., Dines, M., & Bar-Sela, G. (2023). Linkage between psychological factors and response to immune checkpoint inhibitor therapy: A preliminary study. Cells, 12(20), 2471. https://doi.org/10.3390/cells12202471. Link

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D. Dahis, D. M. Azagury, F. Obeid, M. Z. Dion, A. M. Cryer, M. A. Riquelme, P. Dosta, A. W. Abraham, M. Gavish, N. Artzi, Y. Shamay, and H. Azhari, “Focused ultrasound enhances brain delivery of sorafenib nanoparticles,” Advanced NanoBiomed Research, vol. 3, no. 2, p. 2200142, Feb. 2023, doi: 10.1002/anbr.202200142. Link

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S. Launer-Wachs, H. Taub-Tabib, J. T. Madem, O. Bar-Natan, Y. Goldberg, and Y. Shamay, “From centralized to ad-hoc knowledge base construction for hypotheses generation,” J. Biomed. Inform., vol. 142, p. 104383, Jun. 2023, doi: 10.1016/j.jbi.2023.104383. Link

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2022

C. Chen, Z. Yaari, E. Apfelbaum, P. Grodzinski, Y. Shamay, and D. A. Heller, “Merging data curation and machine learning to improve nanomedicines,” Adv. Drug Deliv. Rev., vol. 183, p. 114172, Apr. 2022, doi: 10.1016/j.addr.2022.114172. Link

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Y. Harris, H. Sason, D. Niezni, and Y. Shamay, “Automated discovery of nanomaterials via drug aggregation induced emission,” Biomaterials, vol. 289, p. 121800, Oct. 2022, doi: 10.1016/j.biomaterials.2022.121800. Link

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S. Launer-Wachs, H. Taub-Tabib, Y. Goldberg, and Y. Shamay, “Rapid Knowledgebase Construction and Hypotheses Generation Using Extractive Literature Search,” Feb. 15, 2022, Bioinformatics. doi: 10.1101/2022.02.13.480241. Link

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D. Niezni et al., “Extending the Boundaries of Cancer Therapeutic Complexity with Literature Data Mining,” May 04, 2022, Bioinformatics. doi: 10.1101/2022.05.03.490286. Link

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D. Niezni, Y. Harris, H. Sason, M. Avrashami, and Y. Shamay, “Polydopamine Copolymers for Stable Drug Nanoprecipitation,” Int. J. Mol. Sci., vol. 23, no. 20, p. 12420, Oct. 2022, doi: 10.3390/ijms232012420. Link

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A. Tiktinsky, V. Viswanathan, D. Niezni, D. Meron Azagury, Y. Shamay, H. Taub-Tabib, T. Hope, and Y. Goldberg, “A dataset for N-ary relation extraction of drug combinations,” arXiv preprint arXiv:2205.02289, May 2022. Link

 

2021

N. Bar, J. A. Sobel, T. Penzel, Y. Shamay, and J. A. Behar, “From sleep medicine to medicine during sleep–a clinical perspective,” Physiol. Meas., vol. 42, no. 4, p. 044006, Apr. 2021, doi: 10.1088/1361-6579/abf47c. Link

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J. A. Behar, Y. Shamay, D. Álvarez, F. Del Campo, and T. Penzel, “From sleep medicine to medicine during sleep,” Physiol. Meas., vol. 42, no. 12, p. 120301, Dec. 2021, doi: 10.1088/1361-6579/ac3e38. Link

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M. T. Manzari, Y. Shamay, H. Kiguchi, N. Rosen, M. Scaltriti, and D. A. Heller, “Targeted drug delivery strategies for precision medicines,” Nat. Rev. Mater., vol. 6, no. 4, pp. 351–370, Feb. 2021, doi: 10.1038/s41578-020-00269-6. Link

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I. Maor et al., “Laser-induced thermal response and controlled release of copper oxide nanoparticles from multifunctional polymeric nanocarriers,” Sci. Technol. Adv. Mater., vol. 22, no. 1, pp. 218–233, Dec. 2021, doi: 10.1080/14686996.2021.1883406. Link

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D. Tylawsky et al., “P-selectin Targeting Stimulates Caveolin-1-Mediated Endothelial Transcytosis in Medulloblastoma,” Jul. 16, 2021, In Review. doi: 10.21203/rs.3.rs-658944/v1. Link

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2020

H. Sason and Y. Shamay, “Nanoinformatics in Drug Delivery,” Isr. J. Chem., vol. 60, no. 12, pp. 1108–1117, Dec. 2020, doi: 10.1002/ijch.201900042. Link

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2019

J. D. Harvey, R. M. Williams, K. M. Tully, H. A. Baker, Y. Shamay, and D. A. Heller, “An in Vivo Nanosensor Measures Compartmental Doxorubicin Exposure,” Nano Lett., vol. 19, no. 7, pp. 4343–4354, Jul. 2019, doi: 10.1021/acs.nanolett.9b00956. Link

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O. Perlman, A. Borodetsky, Y. Kauffmann, Y. Shamay, H. Azhari, and I. S. Weitz, “Gold/Copper@Polydopamine Nanocomposite for Contrast-Enhanced Dual Modal Computed Tomography–Magnetic Resonance Imaging,” ACS Appl. Nano Mater., vol. 2, no. 10, pp. 6124–6134, Oct. 2019, doi: 10.1021/acsanm.9b00791. Link

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H. Kodama, Y. Shamay, Y. Kimura, J. Shah, S. B. Solomon, D. Heller, and S. Srimathveeravalli, “Electroporation-induced changes in tumor vasculature and microenvironment can promote the delivery and increase the efficacy of sorafenib nanoparticles,” Bioelectrochemistry, vol. 130, p. 107328, Dec. 2019, doi: 10.1016/j.bioelechem.2019.107328. Link

 

2018

Y. Shamay et al., “Quantitative self-assembly prediction yields targeted nanomedicines,” Nat. Mater., vol. 17, no. 4, pp. 361–368, Apr. 2018, doi: 10.1038/s41563-017-0007-z. Link

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2017

A. Mizrachi et al., “Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma,” Nat. Commun., vol. 8, no. 1, p. 14292, Feb. 2017, doi: 10.1038/ncomms14292. Link

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2016

P. V. Jena, Y. Shamay, J. Shah, D. Roxbury, N. Paknejad, and D. A. Heller, “Photoluminescent carbon nanotubes interrogate the permeability of multicellular tumor spheroids,” Carbon, vol. 97, pp. 99–109, Feb. 2016, doi: 10.1016/j.carbon.2015.08.024. Link

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A. Mizrachi et al., “Tumor-specific PI3K inhibition by targeted delivery in head and neck squamous cell carcinoma,” Eur. J. Cancer, vol. 69, p. S66, Dec. 2016, doi: 10.1016/S0959-8049(16)32786-1. Link

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D. Roxbury, P. V. Jena, Y. Shamay, C. P. Horoszko, and D. A. Heller, “Cell Membrane Proteins Modulate the Carbon Nanotube Optical Bandgap via Surface Charge Accumulation,” ACS Nano, vol. 10, no. 1, pp. 499–506, Jan. 2016, doi: 10.1021/acsnano.5b05438. Link

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Y. Shamay et al., “P-selectin is a nanotherapeutic delivery target in the tumor microenvironment,” Sci. Transl. Med., vol. 8, no. 345, Jun. 2016, doi: 10.1126/scitranslmed.aaf7374. Link

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Y. Shamay, M. Golan, D. Tyomkin, and A. David, “Assessing the therapeutic efficacy of VEGFR-1-targeted polymer drug conjugates in mouse tumor models,” J. Controlled Release, vol. 229, pp. 192–199, May 2016, doi: 10.1016/j.jconrel.2016.03.024. Link

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2015

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A. Golani-Armon, M. Golan, Y. Shamay, L. Raviv, and A. David, “DC3-Decorated Polyplexes for Targeted Gene Delivery into Dendritic Cells,” Bioconjug. Chem., vol. 26, no. 2, pp. 213–224, Feb. 2015, doi: 10.1021/bc500529d. Link

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Y. Shamay, L. Raviv, M. Golan, E. Voronov, R. N. Apte, and A. David, “Inhibition of primary and metastatic tumors in mice by E-selectin-targeted polymer–drug conjugates,” J. Controlled Release, vol. 217, pp. 102–112, Nov. 2015, doi: 10.1016/j.jconrel.2015.08.029. Link

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2014

I. Kogan-Zviagin, Y. Shamay, A. Nissan, O. Sella-Tavor, M. Golan, and A. David, “Intra-colonic administration of a polymer-bound NIRF probe for improved colorectal cancer detection during colonoscopy,” J. Controlled Release, vol. 192, pp. 182–191, Oct. 2014, doi: 10.1016/j.jconrel.2014.06.058. Link

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Y. Shamay, L. Shpirt, G. Ashkenasy, and A. David, “Complexation of Cell-Penetrating Peptide–Polymer Conjugates with Polyanions Controls Cells Uptake of HPMA Copolymers and Anti-tumor Activity,” Pharm. Res., vol. 31, no. 3, pp. 768–779, Mar. 2014, doi: 10.1007/s11095-013-1198-x. Link

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2012

G. Journo-Gershfeld, D. Kapp, Y. Shamay, J. Kopeček, and A. David, “Hyaluronan Oligomers-HPMA Copolymer Conjugates for Targeting Paclitaxel to CD44-Overexpressing Ovarian Carcinoma,” Pharm. Res., vol. 29, no. 4, pp. 1121–1133, Apr. 2012, doi: 10.1007/s11095-012-0672-1. Link

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2011

L. Adar, Y. Shamay, G. Journo, and A. David, “Pro‐apoptotic peptide‐polymer conjugates to induce mitochondrial‐dependent cell death,” Polym. Adv. Technol., vol. 22, no. 1, pp. 199–208, Jan. 2011, doi: 10.1002/pat.1829. Link

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E. Kopansky, Y. Shamay, and A. David, “Peptide-directed HPMA copolymer-doxorubicin conjugates as targeted therapeutics for colorectal cancer,” J. Drug Target., vol. 19, no. 10, pp. 933–943, Dec. 2011, doi: 10.3109/1061186X.2011.632011. Link

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Y. Shamay, L. Adar, G. Ashkenasy, and A. David, “Light induced drug delivery into cancer cells,” Biomaterials, vol. 32, no. 5, pp. 1377–1386, Feb. 2011, doi: 10.1016/j.biomaterials.2010.10.029. Link

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2009

Y. Shamay, D. Paulin, G. Ashkenasy, and A. David, “E-selectin binding peptide–polymer–drug conjugates and their selective cytotoxicity against vascular endothelial cells,” Biomaterials, vol. 30, no. 32, pp. 6460–6468, Nov. 2009, doi: 10.1016/j.biomaterials.2009.08.013. Link

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Y. Shamay, D. Paulin, G. Ashkenasy, and A. David, “Multivalent Display of Quinic Acid Based Ligands for Targeting E-Selectin Expressing Cells,” J. Med. Chem., vol. 52, no. 19, pp. 5906–5915, Oct. 2009, doi: 10.1021/jm900308r. Link